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Lecture 5

Lecture 5 BI315.docx

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Department
Biology
Course
CAS BI 315
Professor
Eric Widmaier
Semester
Spring

Description
Lecture 5 02/16/2014 Ion pumps establish gradients for the diffusion of ions. Membrane is leaky to one or more ions= Vm (membrane potential) The Vm will be closest to the E (equilibrium) of the most permeable ion. If you change the relative permeabilities the membrane potential will change Resistance­structure the resists/doesn’t allow current flow; channels decrease resistance and allow current  flow. Neuroanatomy: Inputs are received on dendrites▯goes to the cell body▯transmits or propagates the signal from the cell  body through the axon.  Dendrites allow for a larger surface area/volume packing lots of contact space in small volume. A given cell  can have many inputs. 100,00 inputs on a single neuron! Some inputs can be stimulatory or not.  You can physically link neurons anatomically.  Neurotransmitters are stored in the axon terminal­gets a signal▯gets released into the space called the  synaptic cleft.  What could you do to K+ to cause depolarization? Close K+ channels/leaky channels and by pumping bring  K+ in but not out.  Na+:ligand gated ion channel receptor: causes an influx of Na+ and causes a depolarization.  4 WAYS TO CAUSE HYPER/DEPOLARIZATION WITH NA,K,K,CL CNS(brain and spinal cord) Interneurons; little cells in the CNS that travel short distances Afferent: brings information TO the CNS FROM the periphery (from sensory receptors) Efferent: leaves CNS­towards periphery (to muscle, gland, other neurons). Innervates­neurons leads to  another structure and causes a response. Pre/Post synaptic to refer to cells Signals that die away are graded signals. Graded post synaptic potential (PSP) EPSP: excitatory post synaptic potential.
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