CAS BI 385 Lecture Notes - Lectin Pathway, Mannose Receptor, Complement Receptor

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Pathogen mechanism: exotoxin release- vibrio cholerae, endotoxin release- y. pestis, direct cytopathic effect. - influenza virus. 3/25/14 12:05 pm: extracellular- interstitial spaces, blood, lymph, epithelial surfaces, intracellular- cytoplasmic. Main goal- opsonization- process of enabling phagocytosis. High energy thioester bond to stick to the pathogen: three pathways, alternative pathway- first one to act on a pathogen. ic3 ic3bb complex c3a and c3b. Once c3b is attached another bb attaches continuously cleaves continues coating pathogen. Properdin (activator) stabilizes c3bbb complex: factor p. Factor h and factor i (inhibit) together decrease. Decay- accelerating factor (daf) leads to bb dissociation and inactivation. Membrane co-factor (mcp) enhances cleave by factor i (acts like factor h: enhance phagocytosis, coats pathogen with cb3 and macrophages have receptors for it. Macrophages express complement receptor 1 (cr1)- arrays of cr1 will recognize arrays of c3b. Preventing attacks on human cells: cd59 prevents recruitment of c9 to form pores.

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