CAS BI 525 Lecture Notes - Lecture 5: Tyrosine Hydroxylase, Pars Compacta, Basal Ganglia
26 Sep 2016
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Class notes for bi525/ne525: lecture 6: parkinson"s disease (part 2) Projections to cerebral cortex, thalamus, certain brain stem nuclei a. iii. Receive input from cerebral cortex and send their output back to cerebral cortex a. iv. Four principal nuclei located in basal ganglia: a. iv. 1. Striatum (caudate nucleus, putamen, ventral striatum including nucleus accumbens) a. iv. 2. Substantia nigra (pars compacta and pars reticulate) a. iv. 4. Subthalamic nuclei: death of snc direct and indirect pathways in physiologic conditions b. i. Main take away there are a lot of ways for this to go wrong and targeting the symptoms could come from the level of the dopaminergic neurons but could also be affected by a down-stream target b. ii. Direct pathway: loss of snc leads to loss of activation of striatum which leads to loss of inhibition of gpi which leads to less inhibition of thalamus which leads to more activation of motor cortices tremors b. iii.
