CAS NE 525 Lecture Notes - Lecture 13: Neurology, Apoptosis, Spasticity
10 Aug 2018
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Document Summary
Neurodegenerative autoimmune disease that progressively robs sufferers of cognitive function, ability to sense the world around them and capacity to walk. Don"t know how it starts neurodegeneration causes autoimmune response or other way around. Autoimmune disease of cns characterized by two stages: inflammation: reaction to autoimmune response, neurodegeneration. Affects wide population, women to men 2 to 1 (due to estrogen regulating neuronal health), age of onset is 25-30. Neurological impairments: depending on neuronal population affected, not one population specifically affected. Most forms are relapsing-remitting form, some chronic progressive and some benign. Relapsing-remitting: phases with flare ups of symptoms and phases where symptoms/disease subsides (inflammation subsides) Chronic progressive: may have relapse and remission but severity of symptoms and duration of flare up are increased. A goal of treatment is to block disease in relapsing- remitting phase so that it doesn"t evolve to chronic progressive. Long lifespan shortened by only 7-8 years thanks to treatments.
