CAS PS 332 Lecture Notes - Lecture 16: Innate Immune System, Antigen, Cytokine

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Explain the main findings from the pittsburgh cold studies : experimental paradigms used, role of stress and social support, proposed physiological pathway. Identify the main findings of research linking stress and wound healing. Distinguish hiv and aids: explain what happens during the three stages of hiv progression. Identify the 7 steps in the hiv life cycle. Identify the primary routes of hiv transmission (routes of infection) Protect body from invasion by antigens: bacteria, viruses, fungi. Remove damaged or mutant cells: e. g. cancer cells. Physical barriers: e. g. skin, mucosal tracts of airway and gut. Innate immune system (nonspecific: general, fast, non-specific response. Acquired immune system (specific: developed much later to fight viruses only, slower, specific response to one antigen. Macrophage: defender cell that is programmed to recognize common antigens: attracted to chemicals released by antigen, travels to side of antigen, reaches out and grabs antigen phagocytosis, literally means big eater . E. g. interleukin 6 (il-6): secreted by t-cells and macrophages.

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