CAS NE 101 Lecture Notes - Lecture 2: Clarity, Rhodopsin, Fear Conditioning
11 Jan 2016
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Every memory you have leaves an imprint on your brain- set of brain cells that represent that thing. The neural cartographer- wilder penfield, extremely accomplished neurosurgeon. Tried to figure out where different experiences were stored. 5% of patients reported vivid recall when being zapped by electrodes- memories, recent and distant, even hallucinations. Can implant electrodes in rats that they can keep there, normally function, watch brain activity. Device is called drive - 128 small wires pulled through, can manipulate height of wires as it goes through brain tissue, real time action potentials, can hear neurons acting. In vivo electrophysiology: recording of action potentials - movement of ions inside or outside. Electrode is detecting flow of ions, seeing wave of positive charge coming in, upward deflection. Intracellular recording regular action potential, relative charge of inside more positive than outside, detect inward influx of na+ Extracellular recording upside down action potential, relative charge of outside becomes more negative.
