CAS NE 102 Lecture Notes - Lecture 4: Ribonucleoside, Transcription Factor Ii H, Tata-Binding Protein
20 Jul 2016
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Ch 7: from dna to protein how cells read the genome. Transcription produces rna that is complimentary to one strand of dna. Rna strand does not remain h-bonded to the dna template strand---dna helix re-forms where rna chain is displaced. Rna polymerase: catalyze formation of phosphodiester bonds that link nucleotides together and form sugar-phosphate backbone of rna chain. Immediate release of rna strand from dna as it is synthesized= many rna copies can be made from the same gene in a short time. Rna polymerase doesn"t need a primer; transcription does not need to be as accurate as. Rna is not used as permanent storage for genetic info in cells. Mistakes in rna transcripts are minor for a cell. Rna polymerase binds to a region of dna called promoter: Specific sequence of nucleotides just upstream of gene to be copied, polymerase will recognize polarity of promoters and latch on to 1 of 2 strands of dna.
