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Class Notes for Neuroscience at Boston University

CAS NE 525 Lecture Notes - Summer 2018, Lecture 15 - Synaptic Plasticity, Neprilysin, Genetically Modified Organism
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ALZHEIMERS DISEASE Two molecular pathways associated with lesions ...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 12 - Scrapie, Jugular Vein, Glycosylphosphatidylinositol
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PRIONS DISEASE (CJD/MAD COW) Transmissible Spongiform Encephalopat...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 13 - Neurology, Apoptosis, Spasticity
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MULTIPLE SCLEROSIS Neurodegenerative Autoimmune Disease that progr...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 11 - Membrane Potential, Axoplasmic Transport, Neurodegeneration
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How are SOD1 aggregates toxic Mitochondrial dysfunctions and apopt...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 14 - Apoptosis, Antigen, T Helper Cell
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Pathology of MS over time Lesions scarring tissue caused by rele...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 16 - Chloroquine, Model Organism, Hydrolase
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Trafficking of APP Biosynthetic pathway: proteins, whether they a...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 2 - Thermodynamics, Folding Funnel, Phosphorylation
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PROTEINS MISFOLDING, AGGREGATION AND NEURODEGENERATION Misfolding: ...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 7 - Atg5, Dnm1L, Mitochondrion
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Proteostasis in PD is disrupted and so the dysfunctional mitochondr...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 4 - Protein Folding, Quality Control, Homeostasis
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APOPTOSIS: programmed cell death Steps: Condensation of ...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 5 - Mitophagy, Heavy Metals, Subthalamic Nucleus
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Mechanisms of Protein Degradation: Ubiquitin Proteasome Pathway: m...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 10 - Superoxide, Mitochondrial Disease, Nitration
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AMYOTROPHIC LATERAL SCLEROSIS (ALS; Lou Gehrigs Disease) Motor neu...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 1 - Basal Ganglia, Prefrontal Cortex, Excitotoxicity
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Parkinsons, ms, als, huntingtons, prions, alzheimers, FTD, down Dif...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 9 - Cytochrome C, Lysosome, Mitochondrial Fission
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ROLE OF HTT IN REST REGULATION HTT sequesters REST in cytosol, les...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 3 - Hydroxyl Radical, Endoplasmic Reticulum, Inner Membrane
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COMMON FEATURES IN NEURODEGENERATIVE DISEASES: Aggregates: beta she...

Neuroscience
CAS NE 525
Lucia Pastorino
CAS NE 525 Lecture Notes - Summer 2018, Lecture 8 - Cytoskeleton, Autophagy, Repressor
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Co-Immuniprecipitation technique (2 examples HT and ALS) STUDY: te...

Neuroscience
CAS NE 525
Lucia Pastorino

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