CAS PS 231 Lecture Notes - Lecture 8: Chlorpromazine, Antipsychotic, Aripiprazole
12 Mar 2018
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Document Summary
Schizophrenia (part 4: antipsychotic/neuroleptic drugs are drugs that tend to relieve schizophrenia and similar conditions. Behavioral benefits develop gradually over a month/+; symptoms return after cessation. Chlorpromazine (thorazine) is a drug used to treat schizophrenia that relieves the positive symptoms of schizophrenia. Each of these drugs block dopamine synapses. For each drug, researchers determined the mean dose prescribed for patients w/schizophrenia (horizontal) and the amount needed to block dopamine receptors (vertical) Pfc greater cognitive impairment: ability of traditional antipsychotic drugs to relieve schizophrenia correlates strongly w how well they block activity at dopamine. The danger of d2 receptor blockers: the mesolimbocortical system is a set of neurons that project from the midbrain tegmentum to the limbic system. Site where drugs that block dopamine synapses produce their benefits: but drugs also block dopamine in the mesostriatal system that projects to basal ganglia. Second-generation antipsychotics (atypical antipsychotics: alleviate schizophrenia & seldom produce movement problems.
