Pathways and methods for dopamine.pdf

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Department
Psychological & Brain Sciences
Course
CAS PS 234
Professor
All Professors
Semester
Spring

Description
Methods  to  study  dopamine  effects  (done  on  rats)     Method   Description   Limitations   Lesions   Inject  toxic  6-­‐OHDA  to  destroy  dopamine.     Can’t  really  see  the  effect  or  role  of   1. When  injected  in  dorsal  striatum-­‐  Parkinson’s   dopamine  in  ventral  striatum.     2. When  injected  in  ventral  striatum -­‐  nothing     In-­‐vivo  Microdialysis   1. Insert  dialysis  probe  in  ventral  striatum.     Equilibrium  takes  about  10  minutes   2. Push  aCSF  through  probe  and  collect  dopamine  from  synapses.   to  reach.     3. Measure  quantity  of  dopamine  after  sample  comes  to  equilibr ium
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