CAS PS 333 Lecture Notes - Lecture 3: Insufflation, Suppository, Selective Serotonin Reuptake Inhibitor

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Caine"s drugs & behavior: pk: route of administration, pills p. o per oral. Advantages: easily administered, slower onset effect isn"t shocking, no needles, doesn"t risk contaminating bloodstream. Disadvantages: not directly to bloodstream, metabolized, first pass metabolism. First pass metabolism in intestine, while drug is being absorbed also trying to be excreted metabolized before desired effect: iv. Need to vaporize the molecules of the drug. Smoke has so many carcinogens (9999) when it is combusted: insufflation. About the same as injections: intramuscular. Abuse potential rapid and brief effect get addicted to it. Pharmacokinetics graph: x-axis is time after administration, y axis is drug concentration in blood. Fda approval: 2 things: better therapeutic effects, less side effects, review classifications (discussion, why are these helpful, behavioral/clinical the drug"s clinical effect (i. e, what problem is it treating) Caine: pharmacodynamic how the drug works in the body (e. g. synaptic mechanism)

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