CAS PS 333 Lecture 10: OL6- Schizophrenia and Antipsychotic Drugs
5 Apr 2018
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Nobel laureates 2000; for dopamine related to pd and schizophrenia. D2 receptor blockade necessary for antipsychotic effects: typical vs atypical antipsychotic drugs: Typical: chlorpromazine (thorazine), haloperidol (haldol) effective with positive symptoms but prone to side effects including parkinsonian side effects (common and early onset) and. Tardive dyskinesia (less common and only occurs with long-term chronic use: atypical antipsychotics: e. g. clozapine (clozaril, not just dopamine d2 blockade also serotonin, including 5ht2a receptors, and possible other. 5ht receptors and other neurotransmitters such as acetylcholine, or undiscovered targets: ameliorates both positive and negative symptoms, lower incidence of side effects, often effective even in treatment-resistant patients. Vta as a therapeutic target: depolarization blockade accumbens as filter for cortex, hippocampus, amygdala: Damaged filtering mechanism may lead to sensory flooding. Hypofrontality (less activity of frontal cortex; possibly related to dopamine in cortex or to abnormally low glutamate function in cortex) cortico-striato-pallido-thalamic circuitries (cortex, accumbens, pallidum, thalamus)
