CAS PS 333 Lecture Notes - Lecture 12: Generalized Anxiety Disorder, Naltrexone, Alcohol By Volume
25 Apr 2018
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Minor tranquilizers: anxiolytic, sedative/hypnotic, anticonvulsant, and anesthetic effects. Historical perspective and chemical classifications: alcohol (oldest) 1912 barbiturates: phenobarbital (luminalr: frank berger (1945): antibacterial agents caused muscle relaxation and tranquilization Meprobomate (miltownr, equanilr) 1955 as an anxiolytic vs. barbiturates (phenobarb) as sedatives: benzodiazepines chlordiazepoxide (libriumr), diazepam (valiumr): leo sternbach/roche (1960s): Librium and vallium delivered on the false promises of meprobomate: choice : 1990s and beyond the benzodiazepines: z drugs , non-gabaergic targets for anxiolytics and sleeping pills: Less abuse liability, dependence and tolerance than phenobarbital (???) Ti ethanol: 1. 2 (bal 0. 30 is anesthetic; bal of 0. 40 is overdose) Ti typical benzodiazepines: seldom fatal unless taken with alcohol. Safety (high ld50 and low ed50); different from phenobarbital ( suicide of. Gabapentin (neuroninr) and other gaba enhancers (e. g. , enzyme inhibitors) Gaba-b drugs (e. g. , baclofen/lioresalr) also used as muscle relaxants. Anxiolytics - drugs used to treat anxiety disorders; most commonly benzodiazepines (bdz)
