CAS PS 333 Lecture Notes - Lecture 13: Ibogaine, Dizocilpine, Intravenous Therapy

• School: Boston University
• Department: Psychological & Brain Sciences
• Course: CAS PS 333
• Professor: Barak Caine

Document Summary

Pcp & ketamine, (cid:1688)date rape(cid:1689) drugs, (cid:1688)laughing gas(cid:1689), anticholinergics lysergic acid diethylamide. Distortions of sensory experience include hallucinations, synesthesia, altered temporal perception, (cid:1684)sense of self(cid:1685) lysergic acid amide found in morning glory seeds. Ergots used historically by midwives to induce childbirth (uterine contraction) Extremely potent: 100 mcg approx. active dose (1 mcg = 1 g = 1 millionth of a gram; 1 mg = 1 thousandth of a gram) Pharmacokinetics: effects begin at 30 min, peak at 90 min; half-life 2 hrs. Pharmacodynamics: (partial) agonist at 5-ht-2a receptors tolerance can be profound (precludes daily use?) (cid:1688)side-effects(cid:1689): paranoid psychoses, depression, (cid:1688)flashbacks(cid:1689), intoxication- induced anxiety (a. k. a. (cid:1688)bad trip(cid:1689)) Peyote buttons (mescaline - from folk medicine mexican indians) Magic mushrooms (psilocybin); very long history 500 b. c. Psilocybin effects may be as a precursor ((cid:1688)prodrug(cid:1689)) of psilocin. Many overlapping effects with lsd (e. g. , pk, tolerance, side-effects)