Drugs, Lec 5: 01/27/2014
New compounds: NCE: new chemical entities: molecules never extracted from the environment or
created by synthetic chemistry. Don’t know what they’ll do to the physiology. No data on what it does in
vivo. Medical schools want to find out what it does.
Drug Doseeffect curve: Dose (xaxis) Effect (yaxis). Ex. interested in sedativehypnotic NCE:
Effect % of rats 100
Asleep 30 mins 50 best fit sigmoid
V 1 3 30 100
Dose (increases left to right) (mg/kg)
Logarithmic scale on base 10. (If 1,2,3 additive, if 5,10,15 geometric). V doesn’t count.
Why logarithmic scale? We don’t know the potency! It matters.
V is vehicle. Vehicle is what you put the drug in to get it to the animal’s body.
You test all of the subjects on both doses. If one is 0% and the other is 100% take a half point (for logs it’s
about a third).
Biphasic drug effec