Drugs, Lec 6: 01/29/2014
A is most potent. A and C are equieffective. D is not effective (shows no doseeffect relationship). B is not
as effective as A and C.
Electrical potential (Action potential) goes from one end of the neuron to the other. NOT
Neurotransmitter. NT is just the currency that is used to transport this action potential. Produces a shock
wave at the nerve terminal. NT’s leak into the synapse, bind to receptors on the dendrite to produce effects.
Indirect agonist: cause more NTs to be present at the synapse.
Direct agonist: not the same entity as the NT but similar enough to the NT to mimic it and directly
stimulate the receptors on the dendrite. Don’t need the endogenous neuron to send the NT into the
Agonist: increases the effect of chemical transmission between the cells.
Antagonist: something that fits into the receptor (like a lock and key) but doesn’t produce any effect by
itself. Blocks the effects of NTs (endogenous agonists) or exogenous agonists (synthetic agonists).
Standard selective antagonists: block certain receptors but not others. Ex. dopamine receptor