Drugs, Lec 6.docx

4 Pages
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Department
Psychological & Brain Sciences
Course Code
CAS PS 333
Professor
Barak Caine

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Drugs, Lec 6: 01/29/2014 A is most potent. A and C are equi­effective. D is not effective (shows no dose­effect relationship). B is not  as effective as A and C.  Electrical potential (Action potential) goes from one end of the neuron to the other. NOT  Neurotransmitter. NT is just the currency that is used to transport this action potential. Produces a shock­ wave at the nerve terminal. NT’s leak into the synapse, bind to receptors on the dendrite to produce effects.  Indirect agonist: cause more NTs to be present at the synapse.  Direct agonist: not the same entity as the NT but similar enough to the NT to mimic it and directly  stimulate the receptors on the dendrite. Don’t need the endogenous neuron to send the NT into the  synapse.  Agonist: increases the effect of chemical transmission between the cells.  Antagonist: something that fits into the receptor (like a lock and key) but doesn’t produce any effect by  itself. Blocks the effects of NTs (endogenous agonists) or exogenous agonists (synthetic agonists).  Standard selective antagonists: block certain receptors but not others. Ex. dopamine receptor  antagonist: haldol Selec
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