Drugs, Lec 12.docx

4 Pages

Psychological & Brain Sciences
Course Code
CAS PS 333
Barak Caine

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Drugs, Lec 12: 02/14/2014 Opioids: History: read from the OL.  Last 10 years are the most important.  Cross out Anesthetics from opioids in the OL. Principal therapeutic effect of opioids is pain relief. Opioids  are not anesthetics and can’t be used as anesthetics, they cause respiratory depression.  Check for heart rate and breathing if someone passed out in respiratory depression. Sometimes if opioids  are used as anesthetics people stop breathing.  Opioids are used for: Analgesics (primary), cough suppressants, anti­diarrheal.  Opium is the oldest used opioid. Used to be smoked.   Opioid addiction used to be called the “war disease”. Starting jerking in bed, a sign of opioid  withdrawal, called it kicking the habit. Gluts, quads and hamstrings would spasm.  Aspirin, not opioid analgesics, don’t bind to opioid receptors but reduce inflammation. Called NSAIDS.  Didn’t work very well, not potent or effective.  Acetyl sciacetic acid is aspirin most effective through oral administration.  Acetylated morphin, diacetyl morphine is heroin. Invented a drug that gives you more morphine than  morphine itself. Brain de­acetylates heroin a
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