Drugs, Lec 13.docx

5 Pages
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Department
Psychological & Brain Sciences
Course Code
CAS PS 333
Professor
Barak Caine

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Description
Drugs, Lec 13:  02/19/2014 #1 reason for accidental deaths in the US. Accidental poisoning. Mostly drug overdose. Mostly opioid  overdose.  All paramedics carry Narcan, narcotic antagonist. What they do on a dose­effect curve: What narcan  does to heroin:  Respiratory Depression                        Dose of heroin (or oxy or vic) Vicodin produces respiratory depression as a side effect. Include dependence (addiction) and tolerance.  Rubatussin: cough suppressant. Binds to glutamate receptors as an antagonist, causes  disorientation and maybe sedation.  Active ingredient of analgesics: oxycodone. Agonist, prescription analgesics:  Percocet: Drug formulation. Two active ingredients useful for treating pain. Per oral codeine (oxycodone)  set (acetaminophen). Mu agonist analgesics with an NSAID: non­steroidal anti­inflammatory agent.  Reducing inflammation will help. Allow you to use a less dose of oxycodone and avoid its harmful side  effects. Oxycodone + acetaminophen.  Percodan: Drug formulation. Two active ingredients useful for treating pain. Oxycodone + aspirin.  Percolone: Oral oxycodone alone. No acetaminophen or aspirin.  Perc 30s: Street name about dose. Don’t know if it has aspirin or acetaminophen content.  Narcan: If taken alone, has some therapeutic uses. Mu opioid receptor antagonists alone. Rescue  from opioids in combination with an agonist overdose. Alone: Increases fertility in  women. Not a brain effect, but mu receptor effect in pituitary gland, alters mu receptors of pituitary  hormones in the ovaries that make women slightly more fertile.  Addiction: if you have an Oxycontine addict, would you give them naloxone or  naltrexone (like Narcan) as a treatment? No, will only cause them to take higher doses of  oxycodone to get high, surmountable antagonists. Also don’t feel anything at all if these antagonists are  used alone. It will induce immediate withdrawal symptoms. Two types of withdrawal:  A. Immediate precipitated withdrawal syndrome: Rapid detoxification. Precipitated  withdrawal. C
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