Drugs, Lec 18: 03/05/2014
Quiz 4 when we come back (Wed).
Frozen addicts favorite drug was Demerol. Prescription opioid analgesic. Mu
Side effect: abuse liability.
Designer drug: MPPP
By product: MPTP. Body coverts it to MPP+ (toxic) through monoamine oxidase. MAO. Killed DA
neurons (cell body) in your substantia nigra. (terminates in the dorsal striatum).
Three main monoamines in your body:
DA, Serotonin, NE. (DA, SHT, NE)
MAOI’s are drugs, such as Deprenyl (G), Selegiline (T). Halt the oxidation of
monoamines. Pargyline is also an MAOI.
Deprenyl stops the degradation of existing Dopamine and makes it last longer before it gets metabolized.
Only bad thing about Ldopa is that people get tolerant to its therapeutic effect
(Voluntary movement), but get increasing side effects (involuntary movements).
Choreac side effects (Huntington’s jerking movements) to antiparkinson’s drugs.
Currently, Ldopa is the leading treatment for Parkinson’s. Second is direct D2
receptor DA agonists, like Pramipexole and Mirapex. Synthetic DA direct agonist.