CAS PS 333 Lecture 3: PS333 OL3
4 Apr 2016
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Document Summary
Opioids have been used for thousands of years by numerous cultures. Sumerians had an idiogram for opium (4000 b. c. e. ) translated as joy plant . Opioids have been used recreationally probably as early as 6000 b. c. e. Historically, used as analgesic, anesthetic, anti-diarrheal, cough medicines sometimes even used to treat addiction. Morphine was most common via injection and codeine via orally first-pass metabolism: codeine was better than morphine, and hydrocodone was better than codeine so that it could be taken orally (doesn"t metabolize/excrete in gi as fast) Drank as laudanum (opium + alcohol) and other tinctures in english cultures. Opium smoking and drinking flourished during the 19th century (e. g. , mrs. Opium supplied illegally to china by the british east india tea company, leading to the opium. Wars and control of hong kong by british. The first legislation in the u. s. related to opium use was passed in 1875 to outlaw opium dens in chinese communities in san francisco.
