BIOL 14a Lecture Notes - Lecture 23: Virus, Herpesviridae, Lysogenic Cycle
3 Nov 2016
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Document Summary
Haplo insufficiency: heterozygous for loss of function non-wt phenotype. The loss of function allele causes a mutant unless extra copy of wt allele is present. C-value = characteristic mass of haploid genome content(dna) per nucleus (in picograms, abt. C-value paradox genome size does not correlate with genome complexity. A very compact genome example viral genome. Very small piece is coded (only about 25,000 protein-coding genes) Transposable elements: a dna sequence that can change its position within a genome ( = te = transposon) Lines (20%) long interspersed dna elements. Sines (11%) short interspersed dna elements. Transcribes dna and then reverse transcriptase to make a double stranded dna copy. Dna sequence is cut with endonuclease and this is then inserted back into the dna sequence. But most of the time, transposition is suppressed. Ex: herpesvirus double stranded, non segmented, dsdna. Zika virus non segmented, single stranded, ssrna, -11kb. Next generation dna sequencing: allows parallel sequencing of large numbers of dna fragments.
