BIOL 0170 Lecture Notes - Lecture 3: Streptococcal Pharyngitis, Vancomycin, Antibiotics
7 Nov 2016
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Surgical sites, central line, ventilator, urinary catheters, c. difficile. Mechanism of infection of cells - 2 week period. Wbcs fighting infection, release of il1 --> fever. Macrophages and neutrophils are the first cells that come try to engulf the bacteria. Fleming"s accidental discovery and isolation of penicillin in 1928. 1940s finally developed, increased life expectancy and used in wwii. Most antibiotics produced by bacteria (produced to defend against other bacteria), fungi, or chemically modified derivatives. New antibiotics made by modifying existing antibiotics (semi-synthetic) or creating new ones (nos), marine organisms (corals being checked for anti-cancer properties), scanning genomes for antibiotic cassettes. As soon as you have a mass population taking antibiotics, the bacterial. As soon as you have a mass population taking antibiotics, the bacterial strain can become resistant to the antibiotic. Inhibition of cell wall synthesis: penicillins, cephalosporins, bacitracin, vancomycin. When bacteria divide, unable to complete cell wall so they die. Inhibition of protein synthesis: chloramphenicol, erythromycin, tetracyclines, streptomycin.
