BIOL 0170 Lecture Notes - Lecture 7: Human Leukocyte Antigen, Hematopoietic Stem Cell Transplantation, Xenotransplantation
7 Nov 2016
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Corneas are number 1 transplanted organ (can even use from diabetic patient) Since 1993, number of donors and transplants performed haven"t changed, but the number of people on waiting list has increased dramatically. Autologous: transplanting tissue from self to another part of the body (ex. skin grafts) Allogeneic: transplant from one individual to another (in the same species) Cadaveric (corneas, acl, ligament reconstructions - anything that is avascular) Brain dead donors (physiologically living but neurologically not) Healthy donors (only solid organ is kidney, bone marrow) Xenogeneic: transplant from a donor of a different species. Stem cells: autologous stem cells (harvested from the individual) Cell surface antigens/proteins, encoded on short arm of chromosome 6 (200 genes) Classes i, ii, iii based on tissue distribution, structure, and function (not rbcs) I, ii genes encode cell surface antigens of nucleated cells and immune cells respectively immune cells respectively. Combination i, ii, iii is called a haplotype (mendelian dominant inheritance)
