BIOL 0170 Lecture Notes - Lecture 6: Overproduction, Menopause, Alendronic Acid
9 Nov 2016
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From small molecules to large proteins: upstream processing. Start with gene of interest, need to figure out how to make and correctly fold the protein. Can use plants, bacteria (e. coli), mammalian cells, yeast to grow the proteins. Must purify and isolate the protein before giving it to the patient. Risk of contamination is very high: downstream processing. Biosimilars: biopharmaceuticals go off patent just like normal pharmaceuticals, creation of biosimilars (generic versions) - 20-30% lower cost (compared to. Includes stratified medicine and individualized medicine: using person"s dna to create therapies specifically targeted and tailored to the individual. The blanket/empirical approach of pharmaceuticals is not as efficient and effective: ex. Responding/not responding to antidepressants, new approach to test if you are a responder before you take the drug. More than 60% of pharmaceutical pipeline projects are coupled with the development of companion diagnostics to make treatments more effective.
