BIOL 0280 Lecture Notes - Lecture 16: Zinc Finger, Zipper, Thymidine

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Dna is an informational molecule, sequence of bases specifies genetic information: within genes: nucleotides specify the aa sequences of proteins, outside of genes: regulatory sequences direct dna replication, mrna synthesis. Polymer of deoxyribonucleotides: bases: a, g, t, c. Bottom sugar half is the same, top base is different. All ring systems, all flat: nucleotides linked by phosphodiester bonds. 5"-->3" polarity, numbers are the numbering of the ribose cs. Linkage is not symmetric, there is directionality: bases are unaffected by the condensation reaction --> remain available for hydrogen bonding. H bonding mediates base-pairing interactions in dna. At = 11. 1a, 2 h bonds formed. Gc = 10. 8a, 3 h bonds formed: base pairing interactions. Hold the 2 strands of dna together, the two strands are antiparallel. Huge advantage because reduced to 4 types of residues that need to be. 3d structure of dna recognized, vs. 20 aa in proteins: watson and crick: structure based on x-ray diffraction experiments of franklin and.

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