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Reference Guide

Nervous System Disorders - Reference Guides

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ANAT - Anatomy
Course Code
ANAT 14
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All

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TM
permacharts
• Muscle weakness • Memory impairment
• Headaches • Pain
Tremors • Fatigue
• Dizziness • Motor disturbances
• Numbness Visual disturbances
• Speech disturbances
The nervous system is composed of
the brain, spinal cord, and nerves, and
is responsible for coordinating the
body’s activities, and sensing and
responding to stimuli • The brain and spinal
cord together make up the central nervous
system (CNS), which processes and stores
motor and sensory information • The remaining
network of nerves throughout the body
constitute the peripheral nervous system
(PNS), which sends impulses to and from the brain
and spinal cord
There are numerous diseases and disorders that
can disrupt the flow of information within the nervous
system, resulting in a variety of symptoms • Such
conditions may be due to injury, infection, heredity
or unknown causes
Paraplegia/Quadriplegia
Paraplegia refers to loss of sensory and motor control of
the lower extremities and sometimes parts of the trunk,
while quadriplegia additionally involves the upper
extremities • These conditions are brought on by severe
spinal cord injury resulting from vertebral fracture or
dislocation, with location and extent of injury to the spinal
cord determining the degree of paralysis (i.e., whether
paraplegia or quadriplegia results) • Both conditions may
involve urinary, bowel, and sexual dysfunction, depending
on the location of damage • Treatment, though not a
guarantee of reversing paralysis, involves realigning the
spinal column and/or decompressing the spinal cord,
nerves, and vertebrae as soon as possible following injury
Disk Prolapse (Herniated Disk)
• In this disorder, the intervertebral disk ruptures and its
pulpy core protrudes, putting pressure on spinal nerve roots
This can be caused by sudden strenuous activity, but
usually is caused by disk degeneration with age
This causes severe pain and, if it impinges on the spinal
cord, possible disability • Disks of the lumbar region are
most often affected (i.e., intervertebral spaces L4/L5, L5/S1,
and L3/L4), with sciatica (pain extending unilaterally from
the buttock to the ankle) resulting if the sciatic nerve is
compressed • If prolapse occurs in the neck, neck pain and
stiffness occur, and sometimes tingling and weakness in the
arms • Treatment consists of extended bed rest, analgesics
for pain relief, and physical therapy, with extreme cases
requiring surgical intervention
Meningitis
Meningitis is a viral or bacterial infection that causes
inflammation of the meninges (membranes that cover the
brain and spinal cord) Viral meningitis is more common,
and is generally mild, with flu-like symptoms • It requires
no treatment, and usually clears up in a few weeks,
with no lasting effects • Bacterial meningitis can be
life-threatening and requires immediate medical treatment
with intravenous antibiotics specific to the infectious agent
The symptoms of bacterial meningitis vary according to
the type of bacteria • Meningococcal meningitis is the
most common, with rapidly-developing flu-like symptoms
followed by drowsiness and sometimes loss of
consciousness • Positive diagnosis is made by lumbar
puncture (removal of a sample of cerebrospinal fluid for
examination) • A vaccine is available, but its success is
limited due to the wide variety of causative factors
SPINAL CORD INJURIES
Neuritis (Neuropathy)
Neuritis is the inflammation and degeneration of
peripheral nerves, resulting in tingling, numbness,
neuralgia (burning feeling) or muscle weakness
• Eventually, paralysis and muscle atrophy may occur in
areas supplied by the affected nerve Various causes have
been identified (e.g., dietary deficiency, chronic alcohol
intoxication, metabolic disorders, toxin poisoning, infectious
diseases), but the cause may be unknown
Bell’s Palsy
Bell’s palsy is paralysis (usually temporary) of the facial
muscles caused by compression of the facial nerve
The compression can be caused by a tumor, trauma
to the nerve, or may be associated with herpes zoster
(shingles) • The patient can display an inability to smile,
close the mouth, grimace or wrinkle the brow, and taste
may be affected • The condition is usually unilateral and
causes the eyelid and corner of the mouth on the affected
side to droop • There may also be pain behind the ear
Treatment involves corticosteroids or adrenocorticotropic
hormone (ACTH) to reduce inflammationFacial muscle
exercises, massage, and application of heat may help
improve muscle tone, and plastic surgery is sometimes
indicated to reduce deformityFull recovery is possible
with early treatment
PERIPHERAL NERVE DISORDERS
Concussion
A violent blow to the head can lead to unconsciousness,
which is referred to as a concussion • This occurs when
electrical brain activity is disturbed, and can last from a
few seconds to several minutes • Dizziness, confusion,
memory loss, and vomiting are common symptoms, and
are more pronounced with a longer period of
unconsciousness • The patient may fall into a coma while
asleep, and should be woken periodically • In most cases,
no permanent brain damage occurs, although treatment by
a physician is recommended if new symptoms develop
Cerebral Contusion
A contusion is bruising of the brain due to severe head
trauma (skin is usually not broken), usually from a blow to
the head or impact with a hard surfaceDepending on the
severity, symptoms can range from temporary loss of
consciousness to a coma, and generally last longer than
24 hours • Symptoms may include blurred vision, unequal
pupils, nausea, and headaches A CT scan will show
extent and location of damage; an X-ray can rule out skull
fracture • Serious contusion may involve a hematoma,
and can result in further sensory and motor disruption
Hematomas
A hematoma is a localized pooling of blood caused by
a broken blood vessel • An epidural hematoma occurs
between the skull and dura mater, and is usually the result
of a blow to the head • A subdural hematoma occurs
between the dura mater and arachnoid membrane, and
usually results when the head strikes a hard surface,
as in a fall • Both types have similar symptoms, but those
of subdural hematomas have delayed onset • Immediate
medical attention is required in both instances
Skull Fractures
When the skull is fractured and the bone fragments push
into the brain (an open or depressed fracture), severe
brain injury can result • Symptoms vary depending on
location, but disappear once the fracture is reduced
• Epilepsy is often a complication of this type of fracture
HEAD INJURIES
INFECTIONS OF THE NERVOUS SYSTEM OVERVIEW
Common Symptoms
Impinging disk
material
Cauda equina
Nerve roots
Spinal ganglion
Lumbar verte-
bral body
Lumbar Disk Prolapse
Scalp Cranium Dura mater Arachnoid
Pia mater Gray matter White matter Meninges
Meninges
Encephalitis
Encephalitis is inflammation of the brain (and the
meninges) generally caused by a viral infection • The virus
can be transmitted by mosquito bite (e.g., St. Louis
encephalitis), infection with herpes simplex virus type 1
(HSV1), infection with HIV or a complication of other viral
infections (e.g., measles, chickenpox, mumps)
• Symptoms include headache, fever, confusion, unsteady
gait, vomiting, stiffness, weakness, visual disturbances, and
lethargy (in serious cases, unilateral paralysis, seizures or
coma) • Acyclovir is used to treat encephalitis caused by
HSV1; if other viruses are involved, there is no effective
treatment (death or permanent brain damage may result)
• Medication can be used to treat symptoms
Reye’s Syndrome
Reye’s syndrome is a brain and liver disorder affecting
children recovering from a viral infection (e.g., upper
respiratory tract infection, chicken pox) • It is related to
taking aspirin for treatment of symptoms caused by
infection; specific cause is unknown • About 1 week after
illness onset, brain swells and liver is invaded by fatty tissue
• Symptoms include vomiting, lethargy, memory loss, liver
dysfunction, confusion, seizures, and coma • There is no
specific treatment; brain swelling can be controlled by
corticosteroids, and blood transfusions or dialysis can help
correct problems from liver dysfunction
Brain Abscess
When infection spreads from elsewhere in the body to the
brain, a collection of pus can form and is referred to as a
brain abscess • Patients exhibit headache and symptoms
specific to the location of the abscess • The most common
sites are the frontal and temporal lobes • Treatment consists
of antibiotics and surgery, but generally some permanent
impairment remains
Nervous System Disorders
Nervous System Disorders
© 2000-2012 Mindsource Technologies Inc. w w w . p e r m a c h a r t s . c o m
2nd EDITION

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Description
p er m a ch a rts MT NNervous System Disorders 2nd EDITION OVERVIEW SPINAL CORD INJURIES INFECTIONS OF THE NERVOUS SYSTEM • The nervous system is composed of Paraplegia/Quadriplegia Meningitis the brain, spinal cord, and nerves, and • Paraplegia refers to loss of sensory and motor cont• Meningitis is a viral or bacterial infection that causes is responsible for coordinating the the lower extremities and sometimes parts of the truninflammation of the meninges (membranes that cover the body’s activities, and sensing and responding to stimuli • The brain and spinal while quadriplegia additionally involves the upper brain and spinal cord) • Viral meningitis is more common, cord together make up the central nervous extremities •These conditions are brought on by severand is generally mild,with flu-like symptoms • It requires system (CNS), which processes and stores spinal cord injury resulting from vertebral fracture no treatment,and usually clears up in a few weeks, dislocation,with location and extent of injury to thewith no lasting effects • Bacterial meningitis can be motor and sensory information • The remaining cord determining the degree of paralysis (i.e.,whethelife-threatening and requires immediate medical treatment network of nerves throughout the body paraplegia or quadriplegia results) • Both conditionswith intravenous antibiotics specific to the infectious agent constitute the peripheral nervous system involve urinary,bowel,and sexual dysfunction,dependin•The symptoms of bacterial meningitis vary according to (PNS), which sends impulses to and from the brain on the location of damage •Treatment,though not a the type of bacteria • Meningococcal meningitis is the and spinal cord guarantee of reversing paralysis,involves realigning most common,with rapidly-developing flu-like symptoms • There are numerous diseases and disorders that spinal column and/or decompressing the spinal cord, followed by drowsiness and sometimes loss of can disrupt the flow of information within the nervonerves,and vertebrae as soon as possible following inconsciousness • Positive diagnosis is made by lumbar system, resulting in a variety of symptoms • Such puncture (removal of a sample of cerebrospinal fluid for conditions may be due to injury, infection, heredityDisk Prolapse (Herniated Disk) examination) •A vaccine is available,but its success is or unknown causes • In this disorder,the intervertebral disk ruptures alimited due to the wide variety of causative factors pulpy core protrudes,putting pressure on spinal nerve roots Common Symptoms •This can be caused by sudden strenuous activity,but  usually is caused by disk degeneration with age • Muscle weakness • Memory impairment •This causes severe pain and,if it impinges on the spinal • Headaches • Pain cord,possible disability • Disks of the lumbar region are  • Tremors • Fatigue most often affected (i.e.,intervertebral spaces L4/L5,L5/S1, • Dizziness • Motor disturbances and L3/L4),with sciatica (pain extending unilaterally from the buttock to the ankle) resulting if the sciatic nerve is  • Numbness • Visual disturbances compressed • If prolapse occurs in the neck,neck pain and • Speech disturbances   stiffness occur,and sometimes tingling and weakness in the arms •Treatment consists of extended bed rest,analgesics  for pain relief,and physical therapy,with extreme cases  HEAD INJURIES requiring surgical intervention Concussion    Lumbar Disk Prolapse  • A violent blow to the head can lead to unconsciousness, Meninges which is referred to as a concussion • This occurs when  Impinging disk electrical brain activity is disturbed, and can last from a material  Scalp  Cranium  Dura mater  Arachnoid few seconds to several minutes • Dizziness, confusion,   Cauda equina  Pia mater  Gray matter  White matter  Meninges memory loss, and vomiting are common symptoms, and  Nerve roots Encephalitis are more pronounced with a longer period of  Spinal ganglion unconsciousness • The patient may fall into a coma while  Lumbar verte- • Encephalitis is inflammation of the brain (and the asleep, and should be woken periodically • In most cases, bral body meninges) generally caused by a viral infection •The virus no permanent brain damage occurs, although treatment by can be transmitted by mosquito bite (e.g.,St.Louis a physician is recommended if new symptoms develop encephalitis),infection with herpes simplex virus type 1  (HSV1),infection with HIV or a complication of other viral Cerebral Contusion infections (e.g.,measles,chickenpox,mumps) • A contusion is bruising of the brain due to severe PERIPHERAL NERVE DISORDERS • Symptoms include headache,fever,confusion,unsteady trauma (skin is usually not broken), usually from a blow to gait,vomiting,stiffness,weakness,visual disturbances,and the head or impact with a hard surface • Depending on thetis (Neuropathy) lethargy (in serious cases,unilateral paralysis,seizures or severity, symptoms can range from temporary loss of • Neuritis is the inflammation and degeneration of coma) • Acyclovir is used to treat encephalitis caused by consciousness to a coma, and generally last longer tperipheral nerves, resulting in tingling, numbness, HSV1; if other viruses are involved,there is no effective 24 hours • Symptoms may include blurred vision, uneqneuralgia (burning feeling) or muscle weakness treatment (death or permanent brain damage may result) pupils, nausea, and headaches • A CT scan will show • Eventually, paralysis and muscle atrophy may occur inedication can be used to treat symptoms extent and location of damage; an X-ray can rule outareas supplied by the affected nerve • Various causes have fracture • Serious contusion may involve a hematoma, Reye’s Syndrome and can result in further sensory and motor disruptionen identified (e.g., dietary deficiency, chronic a• Reye’s syndrome is a brain and liver disorder affecting intoxication, metabolic disorders, toxin poisoning, children recovering from a viral infection (e.g.,upper Hematomas diseases), but the cause may be unknown respiratory tract infection,chicken pox) • It is related to • A hematoma is a localized pooling of blood caused byll’s Palsy taking aspirin for treatment of symptoms caused by a broken blood vessel • An epidural hematoma occurs • Bell’s palsy is paralysis (usually temporary) of the facial; specific cause is unknown •About 1 week after between the skull and dura mater, and is usually the result of a blow to the head • A subdural hematoma occurs muscles caused by compression of the facial nerve illness onset,brain swells and liver is invaded by fatty tissue • The compression can be caused by a tumor, trauma • Symptoms include vomiting,lethargy,memory loss,liver between the dura mater and arachnoid membrane, and to the nerve, or may be associated with herpes zosterysfunction,confusion,seizures,and coma •There is no usually results when the head strikes a hard surface(shingles) • The patient can display an inability to smile,c treatment; brain swelling can be controlled by as in a fall • Both types have similar symptoms, butclose the mouth, grimace or wrinkle the brow, and tasteticosteroids,and blood transfusions or dialysis can help of subdural hematomas have delayed onset • Immediatemay be affected • The condition is usually unilateral andct problems from liver dysfunction medical attention is required in both instances causes the eyelid and corner of the mouth on the affBrain Abscess Skull Fractures side to droop • There may also be pain behind the ear • Treatment involves corticosteroids or adrenocorticotropicnfection spreads from elsewhere in the body to the • When the skull is fractured and the bone fragmentshormone (ACTH) to reduce inflammation • Facial musclerain,a collection of pus can form and is referred to as a into the brain (an open or depressed fracture), seveexercises, massage, and application of heat may helpbrain abscess • Patients exhibit headache and symptoms brain injury can result • Symptoms vary depending onimprove muscle tone, and plastic surgery is sometimespecific to the location of the abscess •The most common location, but disappear once the fracture is reducedindicated to reduce deformity • Full recovery is possible are the frontal and temporal lobes •Treatment consists • Epilepsy is often a complication of this type of fracture of antibiotics and surgery,but generally some permanent with early treatment impairment remains © 2000-2012 Mindsource Technologies Inc. www.permach a rt s .co m permacharts TM EPILEPSY AMYOTROPHIC LATERAL SCLEROSIS CEREBRAL PALSY • Epilepsy is a relatively common disorder of the brain • Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s • Cerebral palsy (CP) is a disorder that impairs motor characterized by recurrent seizures • Many patients disease, is a degenerative disease of the motor neurons, function, caused by damage to the brain (due to lack of experience an aura prior to seizure • There are two types and is the most common motor neuron disease oxygen) sustained before or during birth, or during early of epileptic seizures: partial and generalized • It is relatively rare and affects men slightly
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