BIOS 15115 Lecture Notes - Lecture 8: Cdk Inhibitor, Myc, Cyclin D
7 Sep 2016
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Final will be same format, non-cumulative, some carryover of ideas, ie. what a tyrosine kinase is. Anti-oncogenes (now referred to as tumor suppressor genes: purpose: negatively regulate growth. Must be inactivated or deleted to allow for tumor growth. Retinoblastoma: multiplies, differentiates cells that form the retina (back of the eye, they over-proliferate and form mass in back of the eye instead of differentiating, was a fatal disease, normally early childhood, destroyed brain function, pre-mid. 1800s: once past certain age, cannot occur, ophthalmoscope changed the fatality by allowing optometrists to see back of the eye. Allowed for intervention, eye could be removed and problem was resolved (mid 1800s: familial trend; genetic; also sporadic occurrence (not genetic, early 70s, explained how this could occur. Bilateral: familial, only one event necessary to explain. First somatic mutation = another bad gene added in addition to already-existing bad gene from genetics (one bad gene already inherited) Unilateral: sporadic occurrence; only one event necessary to explain.
