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Lecture 26

BIOL 303 Lecture 26: Chapter 9 - DNAReplication

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Biological Sciences
BIOL 303
Jeffrey Bell

BIOL 303 7 April 2017 “DNA Replication” ● Relies on A pairing with T and G pairing with C ● Semiconservative - e ● Is DNA replication conservative (zeroxing), semiconservative (W&C model) or dispersive (in pieces)? ○ Conservative ○ Semi-conservative ○ Dispersive ● Meselson and Stahl (1958) used heavy nitrogen (^15N) and normal ^14N ● New DNA = ^14N ● Old DNA = ^15N ● Some cells still have the original DNA somewhere in your body “Steps of DNA Replication” ● DNA replication occurs during the S phase of the cycle, prior to cell division ● When DNA is replicated, it separates and hydrogen bonds holding the base pairs together break: ○ Two identical nucleotide chains are built from one, as the bases form pairs ● A site where DNA is locally opened is called a ​replication fork​. “DNA Replication” ● Two strands separate by breaking the hydrogen bonds at replication for ○ This is done by the helicase enzyme ● -ase means “enzyme” ● New strands are bull opposite each of the separated strands using pair rules (A with T and G with C) by DNA polymerase III ● Phosphodiester linkages are made between the sugars and the DNA is twisted into a helix ● On
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