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Class Notes for Biochemistry at Clemson University

BCHM-3050 Lecture Notes - Lecture 13: Dehydration Reaction, Peptide, Hydrolysis
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Polypeptides and Protein Sequences Peptides vs. Polypeptides vs. Proteins Peptide Bonds: also known as amide bonds, and are found between alpha-carboxyl and alpha amino groups Oligopeptides: only...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 19: Globular Protein, Alpha Helix, Beta Sheet
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Globular Proteins Tertiary Structure and Folding Diversity Most of the chemical work of the cell (transporting/metabolizing) is done by globular proteins Their polypeptide chains are f...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 12: Blood Sugar, Diabetes Mellitus Type 1, Insulin Resistance
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Chapter 17 Thursday, June 21, 2013:07 PM Interdependence of major organs in fuel metabolism Major organs: brain, muscle, liver, adipose tissue, heart Major fuel reserves: triacylglycerols (adipose tissue), proteins (skelet...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 12: Oxidative Stress, Isoprene, Q Cycle
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Chapter 14: ETC Monday, June 18, 20189:58 PM Overview of oxidative energy generation Little ATP generation = stage 1 and 2 Produce 10 mol NADH and 2 mol FADH total Per mole glucose Deoxidization of NADH and FADH = most ene...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 17: Insulin Resistance, Insulin Receptor, Diabetes Mellitus Type 2
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Chapter 17: Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates Interdependence of Major Organs Interconnected chemical reactions in a complex multicellular organism Major Organs: br...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 14: Succinic Acid, Q Cycle, Oxidoreductase
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Chapter 14: Electron Transport Overview Relatively little ATP is generated in stage 1 and stage 2. Stages 1 & 2 = product a total of 10 moles of NADH and 2 moles of FADH2 per mole of glucose. Reoxidatio...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 13: Carboxy-Lyases, Hydration Reaction, Isocitric Acid
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Chapter 13: The Citric Acid Cycle Oxidative Processes Circular Pathway citric acid cycle (TCA Cycle/Krebs Cycle) is the central aerobic pathway for oxidizing all metabolic fuels. Entry to this pathway is ac...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 12: Schiff Base, Aldehyde, Cyclic Adenosine Monophosphate
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Chapter 12: Carbohydrate Metabolism Overview of Carbohydrate Catabolic and Anabolic Processes The breakdown of glucose via glycolysis is the beginning of the generation of a large amount of ATP per molecule ...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 10: Thermodynamics, Sphingomyelin, Glycosylphosphatidylinositol
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Chapter 10: Lipids, Membranes, and Cellular Transport Lipid Introduction Major functions: o Energy storage o Membrane Structure o Signaling (hormones) UNLIKE amino acids, nuc...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 11: Furanose, Sucrose, Starch
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Chapter 9: Carbohydrates: Sugars, Saccharides and Glycans Diverse Functions Metabolism storage, and generation of energy (catabolism) Molecular/Cellular Recognition Cellular Protection Cell adhes...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 9: Myoglobin, Hydrogen Bond, Stoichiometry
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Chapter 8: Biological Catalysis Enzymes and Enzyme Classes Enzyme: biological, protein-based catalyst utilized by living organisms to accelerate biological reactions via lowering the activation energy of the...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 8: Van Der Waals Strain, Bohr Effect, Amine
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Chapter 7: Protein Function and Evolution Myoglobin and Hemoglobin Myoglobin (Mb) monomeric heme protein that binds and releases oxygen in tissues. Approximately 2mgg of human muscle tissue for efficient delivery of oxygen...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 7: Hydroxylysine, Collagen, Globular Protein
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Chapter 6: 3D Structure of Proteins 4 Levels of Protein Structure Primary Structure: amino acid (polypeptide) sequence that makes up the protein. Is the direct end result of mRNA translation. Only the peptid...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 6: Edman Degradation, Myoglobin, Hemoglobin
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Chapter 5: Introduction to Proteins Protein Biosynthesis DNA is transcribed to form mRNA in the nucleus (eukaryotes). mRNA is then exported to the cytoplasm via carrier proteins. mRNA is translated in...

Biochemistry
BCHM-3050
Geoffrey Ford
BCHM-3050 Lecture Notes - Lecture 5: Exonuclease, Dna Polymerase I, Dna Polymerase Iii Holoenzyme
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Chapter 22 DNA Replication Information Transfer in the Cell DNA Replication templatedirected duplication of the DNA genome prior to cell division. DNA is separated at forks, and replication begins at one or more fixed site...

Biochemistry
BCHM-3050
Geoffrey Ford

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