GEN-3000 Lecture Notes - Lecture 18: Proteome, Functional Genomics, Protein Structure

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Most rapidly advancing areas of modern genetics. Provides unprecedented information about genomes of different organisms: bioinformatics mathematical software applications: Organize, share and analyze data related to: gene structure, sequence and expression, protein structure and function. Most widely used strategy for sequencing and assembling an entire genome (figure 18-1): of overlapping fragments: genomic d n a cut with restriction enzymes to create series, overlapping fragments aligned using computer programs to assemble entire chromosome. Fragments are aligned based on identical d n a sequences creates contig. One strategy (shown here) involves using restriction enzymes to digest genomic d n a into contigs, which are then sequenced and aligned using bioinformatics to identify overlapping fragments based on sequence identity. Notice that eco r i digestion produces two fragments (contigs 1 and 2 4), whereas digestion with bam h i produces three fragments (contigs 1 2, 3, and 4).

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