MICR-4010 Lecture Notes - Lecture 10: Deinococcus Radiodurans, Candida Albicans, Quorum Sensing
25 Sep 2018
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Ex. deinococcus radiodurans => high radiation tolerance (found by irradiating ground beef) Ex. randomly expressing a gene (stochastic gene expression) Assume that every indiv is expressing about the same amount of enzyme. Actually happens: some of cells produce and some do not. Indivs can produce signal that affects rest of population. Dormancy: cell becomes dormant b/c they run out of nutrients, not in good environment to actively grow. Persister cells: some cells become dormant even if they are involved in active growth. They will live on in the case of environmental change. Persisters survive and will actively grow when antibiotics leave. Can be key to virulence regulators in pathogens. Up to 10% of genome and 20% of proteome is associated w quorum. Cheater cells sensing and the change of candida albicans to become filamentous bacteria. Microbes that dont make something and benefit from others makin it. Saves itself energy because it isn"t making the compound.
