MICR-4160 Lecture Notes - Lecture 2: Organoid, Syncytium, Giant Cell

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The infectious cycle: attachment and entry, translation, genome replication, assembly, release. Either a budding release in the case of enveloped viruses or lysis/release in the case of naked viruses. A specific type of cell from the specific host the virus infects. Susceptible cell: the cell has a functional receptor for a given virus. The cell may or may not be able to support the viral replication, even so, the virus can still enter cell. Resistant cell: has no receptor for the virus to bind. The cell still may or may not be used for viral replication. Permissive cell: cell has the capacity to replicate viruses. If the virus gets into the cell it can replicate but there is no guarantee it can get in. Enders, weller, and robbins: propagated poliovirus in human cell culture (the primary cultures of embryonic tissues). Primary cell lines are mortal and do not grow for a definite period of time.

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