Roles of membrane proteins, membrane protein structure, thermodynamic considerations, absorption of glucose

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Colorado State University
Biochem + Mole Biology
BC 351
Aaron Sholders

Lecture 7Roles of membrane proteinsTransporters structural roles cellsurface receptors exocytosis celltocell adhesion endocytosisMembrane protein structureIntegral vs peripheralPeripheral membrane proteins are proteins that are associated with the surface of the membrane via electrostatic and covalent interactionsIntegral membrane proteins are proteins that have a portion of their structure buried in the lipid bilayerIntegral membrane protein characteristicsIt is not favorable to bury hydrophilic electrostatic charges in a membrane without satisfying their bonding potentialThings to consider in regards to the backbonePeptide bondO hasN has In membrane spanning section there is well formed secondary structure to satisfy chargeshelices satisfy greatlysheets leave a lot unsatisfied unsatisfied bonding potential on edgesFrom barrels rather than sheetsA protein can only be placed in the membrane when the membrane spanning portion adopts secondary structureThings to consider for sidechains in proteins withSingle membrane spanning helicesSidechains almost entirely hydrophobicMultiple membrane spanning helicesMay form hydrophilic core since surroundings are hydrophobic
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