BMS 360 Lecture Notes - Gastrin, Low-Density Lipoprotein, Chymotrypsin

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22 May 2014
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Endocrine: gastrin hcl, motility; histamine hcl. Exocrine: pepsinogen pepsin (from chief cells, transformed by pepsin, hcl); mucus. Stimulus: cck zymogens (trypsin, chymotrypsin, amylase, lipase, carboxypeptidase) Understand blood supply to liver (hepatic portal vein, hepatic artery, entero hepatic circulation) Understand the relationship between fat and glucose metabolism. Synthesize bile salts (entero-hepatic circulation) lipid metabolism. Most fluid is absorbed in the small intestine. Recycling pathway of bile between liver and intestine. Absorption of fat in small intestine chylomicrons. Way fats can be transported through vascular system. Carry triacylglycerol/fat from intestine to liver, skeletal muscle, adipose tissue. Fatty acids and monoglycerides small intestine (epithelial cells) triglycerides chylomicrons lacteals thoracic duct vena cava. Heart arterial system liver and capillaries, skeletal muscle, adipose tissue. Capillary walls lipases free fatty acids absorption in skeletal muscle cells and adipocytes for oxidation and storage, respiration. Chylomicron remnants transformed into very low density lipoproteins (vldl) by liver. Ldl liver and remainder to adipose and muscle.

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