Respiration, pH, respiratory control, chemoreceptors, ventilation, voluntary ventilation, medullary respiratory center

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Colorado State University
Biomedical Science
BMS 360
Douglas Ishii

25 AprilRespiration and pHThe CO produced in tissues is converted in RBC to carbonic acid which dissociates to 2release HCO and HWhere does this acid go3Deoxyhemoglobin reversibly binds H and transports itThis reduces free H so venous blood pH 736 is only slightly more acidic than arterial blood pH 740At the lungs this reaction is reversed to produce CO and waterWith adequate 2ventilation none of the H from cellular respiration normally enters arterial bloodRespiratory acidosis arterial pH735 Due to hypoventilation and increased arterial pCO and H2Respiratory alkalosis arterial pH745 Due to hyperventilation and reduced arterial pCO and H2Respiratory ControlLocalization of peripheral and center control systems that regulate ventilationThe focus will be on chemoreceptorsPeripheral chemoreceptorsCarotid bodyAortic archCentral chemoreceptors in medulla oblongataFig 1333Chemosensory neurons are located in the aorta aortic bodies and in the left and right carotid artery carotid bodiesThese sensory afferent neurons alter CNS regulation of the rate of ventilationFig 1336Chemoreceptors are sensitive to small changes in the carbon dioxide content of the arterial blood to change ventilation rate
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