Compliance, Law of LaPlace

3 Pages

Biomedical Science
Course Code
BMS 420
Charles Miller

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5 September Resistance both downstream (in veins) and upstream (in arteries) affects capillary pressure Veins dilate → pressure in veins decreases Arteriolar dilation → pressure in veins increases Arteriolar constriction → pressure in veins decreases Aorta → vena cava Diameter: large → small → large Thickness: thick → thin → thick Gases and proteins can exchange across the venule Critical closing pressure – forces tending to close the vessel are greater than forces tending to open the vessel E.g. in Raynaud’s disease, in anastomoses Compliance: Δ volume/Δ pressure Higher compliance – greater ability to expand for a given volume Aorta becomes less compliant with age Not linear with changes in pressure When volume gets higher, collagen is more recruited Less stretch, greater pressure Ventricle contraction Ejection Aorta expands Ventricular relaxation Aorta relaxes, creating pressure (elastic recoil) Can be seen as second pump Compliance of vena cava Very compliant at low pressures At higher volumes/pres
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