Henry's Law, Graham's Law, Fick's Law, oxyhemoglobin dissociation curve, oxygen transport, oxygen content

3 Pages
Unlock Document

Colorado State University
Biomedical Science
BMS 420
Charles Miller

7 November Alveolar – arterial O2difference due to shunts between arterial and venous blood 5 – 15 mm Hg normal To know Arterial blood PaO =2100 PaCO =240 Venous blood PVO =240 PVCO =245 Mount Everest PB= 253 mm Hg PO2 = 53 FI =20.21 Fraction of inspired air as oxygen Henry’s Law [O2 dissolved O2x P O2 KO2 – solubility = 0.3 mL O2/100 mL blood 250 mL O d2livered/min Blood flow would have to be 18 times greater without hemoglobin O 2apacity of Hb 1.35 mL O /2 Hb 20 mL O /200 mL blood Bulk flow is the movement of air in response to a driving total pressure (pressure gradient) whereas diffusion is the movement of a particular gas according to its partial pressure gradient. Diffusion occurs until there is no longer a pressure gradient. Henry’s Law describes the fact that a gas in contact with a liquid (plasma) will dissolve in proportion to the partial pressure of that gas. Hence at the respiratory membrane, the higher the partial pressure of oxygen in the alveoli, the greater the amount of oxygen which could potentially dissolve in the plasma. Carbon dioxide is exposed to the systemic capillary blood and Henry’s Law applies. Graham’s Law states that the rate of diffusion of a gas is directly proportional to its solubility coefficient and inversely proportional to the square root of its molecular weight. Fick’s Law – the volume of the gas which flows by diffusion is proportional to the surface area between the blood and the gas, the pressure gradient of the gas, and the diffusion constant for the gas. The diffusion constant (D) is the solubility coefficient divided by the square root of the molecular weight of the gas. A hemoglobin molecule is composed of four protein globin chains, each surrounding a central h
More Less

Related notes for BMS 420

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.