Receptors, local factors affecting blood flow, factors affecting coronary blood flow

2 Pages

Biomedical Science
Course Code
BMS 420
Charles Miller

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10 October Exam 2: Wed Oct 24 Review: Monday in class Oct 22 Quiz Friday Oct 19 Chapters 22+ α receptors – vasoconstriction (norepinephrine) β1receptors - ↑ HR, ↑ contractility β2receptors – vasodilation (epinephrine at low concentration) Higher concentrations of epinephrine causes vasoconstriction Veins do not have β r2ceptors – do not vasodilate 3 local factors affecting blood flow? Tissue factors Endothelial factors Myogenic factors Active hyperemia: ↑ BF due to ↑metabolism → ↑ metabolites Reactive hyperemia: ↑ BF following an occlusion of artery Endothelin is vasoconstrictor Nitric oxide is vasodilator EDHF, PGI ar2 vasodilators Myogenic autoregulation is the other major mechanism involved in control locally and we have discussed it several times. Pressure changes – autoregulation controls flow Protects brain, kidney, etc. Left anterior descending artery – widow maker Aorta → → → coronary sinus → right atrium but also some draina
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