Cardiovascular changes during exercise, impact of blood removal on CO and ABP

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Biomedical Science
BMS 420
Charles Miller

19 October Summary of Cardiovascular Changes During Exercise ↑ Cardiac output ↑ Heart rate (↑ sympathetic adrenergic and ↓ parasympathetic activity) ↑ Stroke volume (↑ CVP; ↑ inotropy; ↑ lusitropy) ↑ Mean arterial pressure and pulse pressure CO increases more than SVR decreases ↑ Stroke volume increases pulse pressure ↑ Central venous pressure Venous constriction (↑ sympathetic adrenergic activity) Muscle pump activity Abdominothoracic pump ↓ Systemic vascular resistance Metabolic vasodilation in active muscle and heart Cutaneous vasodilation (↓ sympathetic adrenergic activity) Vasoconstriction in splanchnic, nonactive muscle, and renal circulation (↑ sympathetic adrenergic activity) HR: may increase to 180 b/min with ANS Stroke volume: increase up to 2 times but plateau reached as filling time of ventricles limited – increased inotropy (atrial/ventricles) and lusitropy Cardiac output: potential to increase 5 – 6 times due to venoconstriction (sympathetic), arterial dilation (metabolites), pumping action of skeletal/respiratory pumps on venous ret
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