NSAIDs, special uses of aspirin, arachidonic acid pathway, cyclooxygenases, selective COX2 inhibitors, Alzheimer's disease, metabolism, side effects, risks, contraindications, drug-drug interactions, acetaminophen

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Biomedical Science
BMS 450
Douglas Ishii

8 MarchPartial list of NSAIDs from list of 3540Sold OTC for oral use hence widespread exposureNaproxen Naprosn Naprelan Aleve AnaproxDicloferac Voltaren CataflamEtodolac LodineNabumetone RelafenKetoprofin Orudis OruvallKetorolac Tordadol parenteralCelecoxib CelebraxAcetylsalicylic acid Aspirin Ecotrin approve for childrenIndomethacin Indocin approved for childrenIbuprofen Advil Motrin Nuprin approved for childrenGeneral Medical Uses of NSAIDsAntiinflammationAntipyretic fever CNS effectAnalgesic for mild to moderate pain nonnarcoticsAnalgesic for nociceptive painAdjuvant for some forms of neuropathic painExamples Injury postoperative dental pain menstrual cramps headaches migraines arthritis tendonitis bursitis fluid filled sacs reduce friction between tendon and boneCancer with mildtomoderate painNSAIDs prevent pain by acting on PNS and CNSDaily doses of aspirin or ibuprofen prevent breast colorectal lung prostate esophageal stomach and ovarian cancers
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