Calcium efflux, digoxin, Frank-Starling law of the heart, calcium sensitizers, vasodilators, excitation-contraction coupling, angiotensin receptor antagonists, alpha adrenergic antagonists, calcium channel antagonists, nitric oxide, protein kinase G

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Biomedical Science
BMS 450
Douglas Ishii

19 AprilDecrease calcium effluxInhibition of the NaCa exchanger decreases calcium effluxGood NaCa exchange inhibitors are not availableLimit NaCa exchanger function indirectlyCardiac glycosidesExample digoxinDigoxinAka digitalis is a purified cardiac glycoside extracted from the foxglove plant Digitalis lanataDigitalis has been used for centuries to treat heart conditionsCardiac glycosides digoxinInhibit the NaK ATPaseLowers intracellular potassiumIncreases intracellular sodiumNaCa exchangerActivity is regulated solely by the concentration of sodium and calcium sodium in the cell willcalcium efflux through the exchangerFrankStarling law of the heartThe heart pumps what it receivesStretching the myocardium with increased preload increase the force of contractionHeart receives more blood it pumps harderStretching the myocardium to increase force of contraction has its limits
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