Metformin, intensive insulin therapy, intensive glucose therapy, mineralocorticoids, cortisol, deoxycorticosterone

4 Pages

Biomedical Science
Course Code
BMS 450
Douglas Ishii

This preview shows page 1. Sign up to view the full 4 pages of the document.
22 FebruaryMetformin increases receptors affinity for insulinCauses receptor clusteringinvaginationReceptors internalized into cellMore insulinmore clusteringmore internalizationpHAcidoticReduces affinity of receptor for insulinWhy in ketoacidosis pH should be corrected before giving insulinObese mice have low sensitivity to insulinPut on dietincreased responsiveness to insulinSame happens to normal mice on fastIn obesityhigh insulin levels internalization of receptors insulin resistant stateAdipose tissue contains substances resistant to insulinPeople in prediabetic state diet and exercise regimenprevent onset of Type II diabetesIntensive insulin therapyMostly Type IFinger prick 4 5x daySmall doses of insulin given to bring glucose levels as close as normal to possible throughout dayMicromanagementPrevent risk of diabetic complications retinopathy nephropathy neuropathy
More Less
Unlock Document

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.