Importance of principles, pharmacokinetic variables affecting drug input/output/response, conversion factors, definitions, formulations, equivalence, drug forms/absorption/bioavailability

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Department
Biomedical Science
Course
BMS 450
Professor
Douglas Ishii
Semester
Spring

Description
23 JanuaryImportance of PrinciplesPotential for harm as well as goodLiterally thousands of drugsBasis for understanding use of any new drugPackage inserts are for normal subjectsHow does one adapt treatment to diseased animals different age or species different body weights revised schedules revise dose in event of underoverdosingIatrogenic disease100000 wrong human prescriptions annually1020 of serious hospital admissionsDrug input absorptiondistributionsteadystate drug concentrationreceptors beneficial toxic and output biotransformation eliminationSome PK pharmacokinetic Variables Affecting Drug InputDrug formRoute of administrationBioavailabilityDose and scheduleAbsorption rateBiotransformationDrug distribution tissue perfusion rateDrugdrug interactions protein bindingIon trapping
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