BMS 460 Lecture Notes - Type Iv Collagen, Monocyte, Esophagitis
26 Apr 2014
School
Department
Course
Professor
Document Summary
Glomerulus is encased in a thin, double walled capsule (bowman"s capsule) which together form the filtering unit. Portion of blood which is filtered into the bowman"s space is known as ultrafiltrate. Glomerular capillary membrane is composed of three layers: capillary endothelial layer, the basement membrane and the single celled capsular epithelial layer. The endothelial layer contains small perforations called fenestrations (fenestrated endothelial cells). Visceral epithelium or podocytes adhere to basement membrane covering capillary endothelial cells. Intercellular clefts or filtration slits formed by interlocking of foot processes (pedicles) of adjacent podocytes. Nephrin, podocin, cd2-associated protein (adhesion molecule) and -actin 4 are exclusively located in slit membrane and are required for normal filtration. Podocyte dysfunction is major cause of many renal diseases. Fenestrae of endothelial cells are maintained by vegf produced by visceral epithelium. The middle basement membrane is a negatively charged selectively permeable network of glycoproteins and mucopolysaccharides and is secreted by and maintained/renewed by epithelial cells.
