BMS 460 Lecture Notes - Phospholamban, Polyphagia, Proteoglycan
26 Apr 2014
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Trh pituitary tsh tsh receptor on thyroid. [ca] calcitonin release by c-cells. Calcitonin enables ca2+ to enter bone osteopetrosis. T4 is converted to active t3 at target tissue by 5"-diodinase action. The t3 binds to nuclear receptors, initiating transcription of a variety of proteins and enzymes. The overall effects of thyroid hormone are to increase metabolic rate and o2 consumption. There is a wide spectrum of general effects in target organs. Mitochondria, respiratory enzymes, na+/k+-atpase, other enzymes o2 consumption, metabolic rate. Normal growth and development of bones, central nervous system. Iodine is cotransported with na+ into follicular cell. Iodide is oxidized and attached to rings of tyrosines in thyroglobulin (tg) via thyroid peroxidase. Tg is synthesized in follicle cell and secreted to colloid. The iodinated ring of one mit or dit is added to a dit at another spot. Endocytosis of thyroglobulin containing t3 and t4 molecules. Lysosomal enzymes release t3 and t4 from tg.
