BMS 460 Lecture Notes - Peritonitis, Keloid, Alpha-1 Antitrypsin
26 Apr 2014
School
Department
Course
Professor
Document Summary
Chemical mediators of inflammation: circulatory changes in inflammation. Tissue injury stimulates the release of a number of chemical mediators that promote varied actions. Plasma-derived ones circulate in inactive form and must be activated by activators demand. Cell-derived ones are preformed stored in granules or synthesized de novo on. Biogenic amines (histamine), peptides (bradykinin, complement), and archidonic acid-derivatives (prostaglandins) Multifunctional: vasodilation or constriction, activation of inflammatory cells, chemotaxis, cytotoxicity, pain, fever. The immediate vascular and smooth muscle reaction to allergen develops within minutes after challenge (allergen exposure in a previously sensitized individual), and the late-phase reaction develops 2 to 24 hr later. The immediate reaction is characterized by vasodilation, congestion, and edema, and the late-phase reaction is characterized by an inflammatory infiltrate rich in eosinophils, neutrophils, and t cells. Immediate vasodilation and increased capillary permeability to form exudate. Vasodilation, increased capillary permeability, pain, fever, potentiate histamine effect. Vasodilation and increased capillary permeability, chemotaxis, increased histamine release.
