BMS 450 Lecture Notes - Biotransformation, Bioavailability, Pharmacokinetics
Document Summary
Basis for understanding use of any new drug. How does one adapt treatment to: diseased animals, different age or species, different body weights, revised schedules, revise dose in event of under/over-dosing. Drug input (absorption & distribution) steady-state drug concentration receptors (beneficial, toxic) and output (biotransformation, elimination) Begin with a qualitative understanding of the variables. Review and practice math and chemistry skills and do problem sets. 1 ml water = 1 g (standard conditions) 10% v/v = 10 ml drug per 100 ml liquid. 10% w/w = 10 g drug per 100 g powder. 10% w/v = 10 g drug per 100 ml liquid. Know what 1 m, 1 mm, and 1 m mean. Syllabus review: pages 26 31, page 8c q3 & 4. Pharmacology the science of drugs in the body. Therapeutic equivalence: same population response to api in clinical trials. Clinical trial: placebo controlled, double-blind, multicenter, 100 million. Gases passively diffuse into blood, high bioavailability.
