BMS 450 Lecture Notes - Carbonic Anhydrase Inhibitor, Phosphodiesterase Inhibitor, Angina Pectoris
Document Summary
Stable organic nitrates capable of delivering no to the vasculature. Medical formulations contain small amounts diluted in inert material and are not explosive. Manage angina pectoris (chest pain) associated with ischemic heart disease. A freshly prepared solution is slightly brownish, should be discarded if the color is dark brown, orange, or blue. Cgmp levels leads to pkg activity. Pde type 5 is found most prominently in the penile corpus cavernosum. No released during sexual stimulation activates guanylyl cyclase, resulting in increased levels of cgmp cgmp causes smooth muscle relaxation in the corpus cavernosum allowing the inflow of blood. Pde5 inhibitors prevent the breakdown of cgmp, thereby prolonging its actions. Open potassium channels in vascular smooth muscle cells. Potassium conductance hyperpolarizes the smooth muscle cell membrane. Hyperpolarization the opening of calcium channels thus calcium entry and contraction. Has been used to treat hypertension during pregnancy in the past. Stuff going from the blood into the tubular lumen.
