Class Notes (838,386)
United States (325,381)
Chemistry (249)
CHEM 341 (46)
Lecture

Alcohol substitution/elimination, ether substitution, epoxides, organometallics

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Department
Chemistry
Course
CHEM 341
Professor
Debbie Crans
Semester
Fall

Description
2 November Alcohol Substitution - - Recall: OH and RO are horrible leaving groups But: H 2 is a good leaving group Alcohol Substitution: Other Methods Strategy: Activate alcohol and displace in same pot SOCL (t2ionyl chloride) PBr 3phosphorous tribromide) Sulfate esters Introduce nucleophile in second step Alcohol Elimination – Dehydration Reverse of alkene hydration: use non-nucle
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