Class Notes (834,627)
United States (323,834)
Life Science (261)
LIFE 102 (201)
Lecture

Histone modifications, DNA methylation, epigenetics, transcription factors, coordinately controlled genes, post-transcriptional regulation, effects on mRNAs, differential gene expression

5 Pages
119 Views
Unlock Document

Department
Life Science
Course
LIFE 102
Professor
Louis Bjostad
Semester
Spring

Description
20 AprilFinal is not cumulativeHistone ModificationsIn histone acetylation acetyl groups are attached to positively charged lysines in histones tailsThis loosens chromatin structure thereby promoting the initiation of transcriptionThe addition of methyl groups methylation can condense chromatinThe addition of phosphate groups phosphorylation next to a methylated amino acid can loosen chromatinThe histone code hypothesis proposes that specific combinations of modifications help determine chromatin configuration and influence transcriptionDNA MethylationDNA methylation the addition of methyl groups to certain bases in DNA is associated with reduced transcription in some speciesDNA methylation can cause longterm inactivation of genes in cellular differentiationIn genomic imprinting methylation regulates expression of either the maternal or paternal alleles of certain genes at the start of developmentEpigenetic InheritanceAlthough the chromatin modifications just discussed do not alter DNA sequence they may be passed to future generations of cellsThe inheritance of traits transmitted by mechanisms not directly involving the nucleotide sequence is called epigenetic inheritanceRegulation of Transcription InitiationChromatinmodifying enzymes provide initial control of gene expression by making a region of DNA either more or less able to bind the transcription machineryOrganization of a Typical Eukaryotic Gene
More Less

Related notes for LIFE 102

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit